Assay Detail
Functional
CHEMBL713288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of growth-factor-stimulated MDA-MB-453 breast cancer cell proliferation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349373 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349373 | — | IC50 | = | 600.0 | nM | 6.22 |