Assay Detail
Functional
CHEMBL713354
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Growth inhibitory activity on MDA-435/LCC6-MDRI (Pgp-negative) human breast cancer cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.83 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.96 |
| CHEMBL131172 | — | — | 1 | 5.14 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 4.44 |
| CHEMBL129251 | — | — | 1 | 4.42 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL131172 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL129251 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 63400.0 | nM | 4.20 |