Assay Detail
Functional
CHEMBL713409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
1-Arylsulfonyl-3-(-hydroxybenzyl)-1H-pyrroles, a novel class of anti-HIV-1 reverse transcriptase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 5.40 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.60 |
| CHEMBL301913 | — | — | 1 | 6.52 |
| CHEMBL60805 | — | — | 1 | 6.52 |
| CHEMBL59226 | — | — | 1 | 5.82 |
| CHEMBL57709 | — | — | 1 | 5.77 |
| CHEMBL301449 | — | — | 1 | 5.75 |
| CHEMBL60866 | — | — | 1 | 5.60 |
| CHEMBL418282 | — | — | 1 | 5.50 |
| CHEMBL292808 | — | — | 1 | 5.39 |
| CHEMBL59133 | — | — | 1 | 5.36 |
| CHEMBL293538 | — | — | 1 | 5.30 |
| CHEMBL293787 | ETHYL PYROPHOSPHATE | -1.0 | 1 | 5.16 |
| CHEMBL294602 | — | — | 1 | 5.14 |
| CHEMBL58696 | — | — | 1 | 5.10 |
| CHEMBL299234 | — | — | 1 | 5.05 |
| CHEMBL299240 | — | — | 1 | 5.04 |
| CHEMBL292878 | — | — | 1 | 5.01 |
| CHEMBL418634 | — | — | 1 | 4.96 |
| CHEMBL58317 | — | — | 1 | 4.85 |
| CHEMBL300354 | — | — | 1 | 4.82 |
| CHEMBL56920 | — | — | 1 | 4.80 |
| CHEMBL299235 | — | — | 1 | 4.80 |
| CHEMBL301026 | — | — | 1 | 4.66 |
| CHEMBL58576 | — | — | 1 | 4.66 |
| CHEMBL291945 | — | — | 1 | 4.32 |
| CHEMBL294001 | — | — | 1 | - |
| CHEMBL57795 | — | — | 1 | - |
| CHEMBL57753 | — | — | 1 | - |
| CHEMBL58994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL60805 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL301913 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL59226 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL57709 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL301449 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL60866 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL418282 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL292808 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL59133 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL293538 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL293787 | ETHYL PYROPHOSPHATE | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL294602 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL58696 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL299234 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL299240 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL292878 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL418634 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL58317 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL300354 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL56920 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL299235 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL301026 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL58576 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL291945 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL60485 | — | EC50 | > | 26000.0 | nM | - |
| CHEMBL57885 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL61187 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL57602 | — | EC50 | > | 26000.0 | nM | - |
| CHEMBL57752 | — | EC50 | > | 82000.0 | nM | - |
| CHEMBL58733 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL57304 | — | EC50 | > | 28000.0 | nM | - |
| CHEMBL291989 | — | EC50 | > | 95000.0 | nM | - |
| CHEMBL58994 | — | EC50 | > | 22000.0 | nM | - |
| CHEMBL57753 | — | EC50 | > | 14000.0 | nM | - |
| CHEMBL57795 | — | EC50 | > | 14000.0 | nM | - |
| CHEMBL294001 | — | EC50 | > | 25000.0 | nM | - |