Assay Detail
Functional
CHEMBL713419
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Effective concentration achieving 50% protection of MT-4 cells against the cytopathic effect of HIV-1
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.99 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | 2.0 | 1 | 9.00 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.52 |
| CHEMBL3350657 | — | — | 1 | 6.05 |
| CHEMBL3350648 | — | — | 1 | 5.94 |
| CHEMBL3350659 | — | — | 1 | 5.89 |
| CHEMBL3350646 | — | — | 2 | 4.45 |
| CHEMBL3350661 | — | — | 1 | 4.05 |
| CHEMBL3350649 | — | — | 1 | - |
| CHEMBL3350662 | — | — | 1 | - |
| CHEMBL3350660 | — | — | 1 | - |
| CHEMBL3350656 | — | — | 1 | - |
| CHEMBL3350654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105318 | ALOVUDINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3350657 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3350648 | — | EC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL3350659 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3350646 | — | EC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL3350661 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3350646 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3350649 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL3350662 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL3350660 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL3350656 | — | EC50 | = | 500000.0 | nM | - |
| CHEMBL3350654 | — | EC50 | = | 500000.0 | nM | - |