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Assay Detail

CHEMBL713420

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration against HIV-1 induced cytopathogenicity in MT-4 cells
ChEMBL ↗
47
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Mai A, Sbardella G, Artico M, Ragno R, Massa S, Novellino E, Greco G, Lavecchia A, Musiu C, La Colla M, Murgioni C, La Colla P, Loddo R.
J Med Chem (2001) 44 : 2544 -2554
PubMed 11472208 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 47 6.85 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL236161 — — 3 8.70
CHEMBL85947 — — 1 8.15
CHEMBL85834 — — 1 8.10
CHEMBL82569 — — 1 8.00
CHEMBL87226 — — 1 7.75
CHEMBL85946 — — 1 7.52
CHEMBL309674 — — 1 7.52
CHEMBL35033 EMIVIRINE 2.0 1 7.52
CHEMBL85992 — — 1 7.52
CHEMBL310803 — — 1 7.40
CHEMBL87393 — — 1 7.40
CHEMBL87451 — — 1 7.30
CHEMBL87235 — — 1 7.30
CHEMBL87279 — — 1 7.30
CHEMBL421535 — — 1 7.30
CHEMBL83140 — — 1 7.30
CHEMBL83352 — — 1 7.30
CHEMBL313751 — — 1 7.16
CHEMBL309899 — — 1 7.10
CHEMBL312874 — — 1 7.10
CHEMBL85798 — — 1 7.10
CHEMBL85949 — — 1 6.85
CHEMBL87542 — — 1 6.82
CHEMBL83870 — — 1 6.80
CHEMBL314925 — — 1 6.75
CHEMBL83401 — — 1 6.75
CHEMBL420971 — — 1 6.64
CHEMBL57 NEVIRAPINE 4.0 1 6.52
CHEMBL313930 — — 1 6.40
CHEMBL314829 — — 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL236161 — EC50 = 2.0 nM 8.70
CHEMBL236161 — EC50 = 6.0 nM 8.22
CHEMBL85947 — EC50 = 7.0 nM 8.15
CHEMBL85834 — EC50 = 8.0 nM 8.10
CHEMBL82569 — EC50 = 10.0 nM 8.00
CHEMBL87226 — EC50 = 18.0 nM 7.75
CHEMBL309674 — EC50 = 30.0 nM 7.52
CHEMBL35033 EMIVIRINE EC50 = 30.0 nM 7.52
CHEMBL85946 — EC50 = 30.0 nM 7.52
CHEMBL85992 — EC50 = 30.0 nM 7.52
CHEMBL310803 — EC50 = 40.0 nM 7.40
CHEMBL87393 — EC50 = 40.0 nM 7.40
CHEMBL87279 — EC50 = 50.0 nM 7.30
CHEMBL83352 — EC50 = 50.0 nM 7.30
CHEMBL83140 — EC50 = 50.0 nM 7.30
CHEMBL87235 — EC50 = 50.0 nM 7.30
CHEMBL87451 — EC50 = 50.0 nM 7.30
CHEMBL421535 — EC50 = 50.0 nM 7.30
CHEMBL236161 — EC50 = 70.0 nM 7.16
CHEMBL313751 — EC50 = 70.0 nM 7.16
CHEMBL309899 — EC50 = 80.0 nM 7.10
CHEMBL85798 — EC50 = 80.0 nM 7.10
CHEMBL312874 — EC50 = 80.0 nM 7.10
CHEMBL85949 — EC50 = 140.0 nM 6.85
CHEMBL87542 — EC50 = 150.0 nM 6.82
CHEMBL83870 — EC50 = 160.0 nM 6.80
CHEMBL83401 — EC50 = 180.0 nM 6.75
CHEMBL314925 — EC50 = 180.0 nM 6.75
CHEMBL420971 — EC50 = 230.0 nM 6.64
CHEMBL57 NEVIRAPINE EC50 = 300.0 nM 6.52
CHEMBL314829 — EC50 = 400.0 nM 6.40
CHEMBL313930 — EC50 = 400.0 nM 6.40
CHEMBL86015 — EC50 = 500.0 nM 6.30
CHEMBL315450 — EC50 = 600.0 nM 6.22
CHEMBL315287 — EC50 = 600.0 nM 6.22
CHEMBL87569 — EC50 = 800.0 nM 6.10
CHEMBL85368 — EC50 = 900.0 nM 6.05
CHEMBL85274 — EC50 = 1000.0 nM 6.00
CHEMBL87637 — EC50 = 1000.0 nM 6.00
CHEMBL83193 — EC50 = 1000.0 nM 6.00
CHEMBL86289 — EC50 = 1100.0 nM 5.96
CHEMBL85699 — EC50 = 1200.0 nM 5.92
CHEMBL86062 — EC50 = 1300.0 nM 5.89
CHEMBL314572 — EC50 = 1500.0 nM 5.82
CHEMBL83402 — EC50 = 2900.0 nM 5.54
CHEMBL315215 — EC50 = 3000.0 nM 5.52
CHEMBL314159 — EC50 = 3600.0 nM 5.44