Assay Detail
Functional
CHEMBL713512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.23 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304294 | — | — | 1 | 7.64 |
| CHEMBL163664 | — | — | 1 | 7.58 |
| CHEMBL352774 | — | — | 1 | 7.47 |
| CHEMBL349271 | — | — | 1 | 7.22 |
| CHEMBL65881 | — | — | 1 | 7.11 |
| CHEMBL307994 | — | — | 1 | 6.80 |
| CHEMBL354277 | — | — | 1 | 6.17 |
| CHEMBL350982 | — | — | 1 | 5.94 |
| CHEMBL68933 | — | — | 1 | 4.87 |
| CHEMBL66043 | — | — | 1 | 4.84 |
| CHEMBL348749 | — | — | 1 | 4.64 |
| CHEMBL68175 | — | — | 1 | 4.49 |
| CHEMBL351008 | — | — | 1 | - |
| CHEMBL164708 | — | — | 1 | - |
| CHEMBL167899 | — | — | 1 | - |
| CHEMBL353000 | — | — | 1 | - |
| CHEMBL349912 | — | — | 1 | - |
| CHEMBL354789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304294 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL163664 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL352774 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL349271 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL65881 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL307994 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL354277 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL350982 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL68933 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL66043 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL348749 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL68175 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL351008 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL164708 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL167899 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL353000 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL349912 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL354789 | — | IC50 | > | 250000.0 | nM | - |