Assay Detail
Functional
CHEMBL713685
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Anti-HIV-1 activity against K103N strain in MT-4 cells by the MTT method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.12 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233664 | — | — | 1 | 8.52 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 7.50 |
| CHEMBL338047 | — | — | 1 | 7.50 |
| CHEMBL136862 | — | — | 1 | 7.50 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL137851 | — | — | 1 | 7.40 |
| CHEMBL319139 | — | — | 1 | 7.40 |
| CHEMBL137117 | — | — | 1 | 7.30 |
| CHEMBL344591 | — | — | 1 | 7.00 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.60 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233664 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL338047 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL136862 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL137851 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL319139 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL137117 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL344591 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 6300.0 | nM | 5.20 |