Assay Detail
Binding
CHEMBL713705
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Inhibition of Matrix metalloprotease-1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.46 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11306 | — | — | 1 | 8.52 |
| CHEMBL123571 | — | — | 1 | 7.92 |
| CHEMBL126122 | — | — | 1 | 7.60 |
| CHEMBL338231 | — | — | 1 | 7.54 |
| CHEMBL125553 | — | — | 1 | 7.33 |
| CHEMBL124623 | — | — | 1 | 5.85 |
| CHEMBL122591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11306 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL123571 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL126122 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL338231 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL125553 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL124623 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL122591 | — | IC50 | > | 1000.0 | nM | - |