Assay Detail
Functional
CHEMBL713880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration required to inhibit murine cytomegalovirus (MCMV) replication in MEF cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MEF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.08 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | 6.57 |
| CHEMBL155623 | — | — | 1 | 5.70 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.30 |
| CHEMBL157102 | — | — | 1 | 5.01 |
| CHEMBL154409 | — | — | 1 | 4.72 |
| CHEMBL2111213 | — | — | 1 | 4.72 |
| CHEMBL347817 | — | — | 1 | 4.38 |
| CHEMBL151794 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265948 | FILOCICLOVIR | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL155623 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL157102 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL154409 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL2111213 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL347817 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL151794 | — | EC50 | = | 54000.0 | nM | 4.27 |