Assay Detail
Functional
CHEMBL713946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1.
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.91 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66155 | — | — | 1 | 7.92 |
| CHEMBL420367 | — | — | 1 | 7.34 |
| CHEMBL420740 | — | — | 1 | 6.84 |
| CHEMBL168006 | — | — | 1 | 6.75 |
| CHEMBL66043 | — | — | 1 | 5.65 |
| CHEMBL69517 | — | — | 1 | 4.92 |
| CHEMBL69775 | — | — | 1 | 4.90 |
| CHEMBL305070 | — | — | 2 | 4.59 |
| CHEMBL304317 | — | — | 1 | 4.32 |
| CHEMBL167881 | — | — | 1 | - |
| CHEMBL354236 | — | — | 1 | - |
| CHEMBL163954 | — | — | 1 | - |
| CHEMBL163882 | — | — | 1 | - |
| CHEMBL168190 | — | — | 1 | - |
| CHEMBL165138 | — | — | 1 | - |
| CHEMBL349269 | — | — | 1 | - |
| CHEMBL166746 | — | — | 1 | - |
| CHEMBL164494 | — | — | 1 | - |
| CHEMBL166809 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66155 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL420367 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL420740 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL168006 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL66043 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL69517 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL69775 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL305070 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL304317 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL167881 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL354236 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL163954 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL305070 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL168190 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL165138 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL349269 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL166746 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL164494 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL166809 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL163882 | — | IC50 | > | 250000.0 | nM | - |