Assay Detail
Binding
CHEMBL713990
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Inhibition of Matrix metalloprotease-1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.80 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.82 |
| CHEMBL323371 | — | — | 1 | 7.51 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 7.32 |
| CHEMBL317132 | — | — | 1 | 7.13 |
| CHEMBL317508 | — | — | 1 | 6.94 |
| CHEMBL101121 | — | — | 1 | 6.12 |
| CHEMBL100805 | — | — | 1 | 5.54 |
| CHEMBL100584 | — | — | 1 | 5.02 |
| CHEMBL103442 | — | — | 1 | - |
| CHEMBL318795 | — | — | 1 | - |
| CHEMBL38851 | — | — | 1 | - |
| CHEMBL102459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL323371 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL317132 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL317508 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL101121 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL100805 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL100584 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL103442 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL318795 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL38851 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL102459 | — | IC50 | > | 10000.0 | nM | - |