Assay Detail
Binding
CHEMBL713993
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Inhibition of human matrix metalloprotease-1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Receptor flexibility in the in silico screening of reagents in the S1' pocket of human collagenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.28 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328903 | — | — | 1 | 8.89 |
| CHEMBL96771 | — | — | 1 | 8.00 |
| CHEMBL90978 | — | — | 1 | 7.66 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.57 |
| CHEMBL92608 | — | — | 1 | 7.40 |
| CHEMBL450875 | — | — | 1 | 7.05 |
| CHEMBL330067 | — | — | 1 | 6.92 |
| CHEMBL329689 | — | — | 1 | 6.86 |
| CHEMBL92077 | — | — | 1 | 6.44 |
| CHEMBL316676 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328903 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL96771 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL90978 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL92608 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL450875 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL330067 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL329689 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL92077 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL316676 | — | IC50 | = | 920.0 | nM | 6.04 |