Assay Detail
Binding
CHEMBL714115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.58 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27007 | — | — | 1 | 7.48 |
| CHEMBL430724 | — | — | 1 | 7.36 |
| CHEMBL26678 | — | — | 1 | 7.21 |
| CHEMBL28629 | — | — | 1 | 7.15 |
| CHEMBL27191 | — | — | 1 | 7.11 |
| CHEMBL29743 | — | — | 1 | 7.10 |
| CHEMBL26779 | — | — | 1 | 7.06 |
| CHEMBL418382 | — | — | 1 | 7.05 |
| CHEMBL281496 | — | — | 1 | 7.01 |
| CHEMBL281326 | — | — | 1 | 6.97 |
| CHEMBL25903 | — | — | 1 | 6.96 |
| CHEMBL27257 | — | — | 1 | 6.95 |
| CHEMBL25731 | — | — | 1 | 6.94 |
| CHEMBL284024 | — | — | 1 | 6.93 |
| CHEMBL27536 | — | — | 1 | 6.91 |
| CHEMBL27415 | — | — | 1 | 6.89 |
| CHEMBL25867 | — | — | 1 | 6.88 |
| CHEMBL26039 | — | — | 1 | 6.86 |
| CHEMBL30052 | — | — | 1 | 6.83 |
| CHEMBL26150 | — | — | 1 | 6.78 |
| CHEMBL284676 | — | — | 1 | 6.76 |
| CHEMBL283438 | — | — | 1 | 6.74 |
| CHEMBL282156 | — | — | 1 | 6.74 |
| CHEMBL287400 | — | — | 1 | 6.65 |
| CHEMBL285343 | — | — | 1 | 6.65 |
| CHEMBL439727 | — | — | 1 | 6.64 |
| CHEMBL27128 | — | — | 1 | 6.63 |
| CHEMBL25905 | — | — | 1 | 6.61 |
| CHEMBL283253 | — | — | 1 | 6.58 |
| CHEMBL283255 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27007 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL430724 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL26678 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL28629 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL27191 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL29743 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL26779 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL418382 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL281496 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL281326 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL25903 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL27257 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL25731 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL284024 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL27536 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL27415 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL25867 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL26039 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL30052 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL26150 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL284676 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL283438 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL282156 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL287400 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL285343 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL439727 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL27128 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL25905 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL283253 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL283255 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL282365 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL430925 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL286948 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL28584 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL26081 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL29631 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL281235 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL283693 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL431503 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL26686 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL26369 | — | IC50 | = | 1235.0 | nM | 5.91 |
| CHEMBL28168 | — | IC50 | = | 1255.0 | nM | 5.90 |
| CHEMBL25972 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL287181 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL281284 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL281743 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL286963 | — | IC50 | = | 3440.0 | nM | 5.46 |