Assay Detail
Binding
CHEMBL714116
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Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.09 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27102 | — | — | 1 | 7.37 |
| CHEMBL26485 | — | — | 1 | 7.21 |
| CHEMBL280981 | — | — | 1 | 7.12 |
| CHEMBL26635 | — | — | 1 | 6.98 |
| CHEMBL286272 | — | — | 1 | 6.92 |
| CHEMBL26599 | — | — | 1 | 6.86 |
| CHEMBL282819 | — | — | 1 | 6.66 |
| CHEMBL26795 | — | — | 1 | 6.64 |
| CHEMBL282610 | — | — | 1 | 6.40 |
| CHEMBL27172 | — | — | 1 | 6.39 |
| CHEMBL27171 | — | — | 1 | 6.28 |
| CHEMBL26892 | — | — | 1 | 6.27 |
| CHEMBL283835 | — | — | 1 | 6.24 |
| CHEMBL27861 | — | — | 1 | 6.22 |
| CHEMBL27709 | — | — | 1 | 6.21 |
| CHEMBL285576 | — | — | 1 | 6.19 |
| CHEMBL282592 | — | — | 1 | 6.17 |
| CHEMBL28098 | — | — | 1 | 6.16 |
| CHEMBL27497 | — | — | 1 | 6.15 |
| CHEMBL27823 | — | — | 1 | 6.05 |
| CHEMBL28061 | — | — | 1 | 6.04 |
| CHEMBL281252 | — | — | 1 | 6.04 |
| CHEMBL27517 | — | — | 1 | 6.02 |
| CHEMBL282151 | — | — | 1 | 5.86 |
| CHEMBL26934 | — | — | 1 | 5.85 |
| CHEMBL27834 | — | — | 1 | 5.73 |
| CHEMBL26017 | — | — | 1 | 5.64 |
| CHEMBL27452 | — | — | 1 | 5.55 |
| CHEMBL281938 | — | — | 1 | 5.41 |
| CHEMBL27841 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27102 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL26485 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL280981 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL26635 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL286272 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL26599 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL282819 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL26795 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL282610 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL27172 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL27171 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL26892 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL283835 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL27861 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL27709 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL285576 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL282592 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL28098 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL27497 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL27823 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL28061 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL281252 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL27517 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL282151 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL26934 | — | IC50 | = | 1415.0 | nM | 5.85 |
| CHEMBL27834 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL26017 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL27452 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL281938 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL27841 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL282611 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL285830 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL26707 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL27634 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL27524 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL26530 | — | IC50 | > | 50000.0 | nM | - |