Assay Detail
Functional
CHEMBL714126
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Agonist activity against MCF-7 cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7S |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.60 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157972 | — | — | 1 | 9.85 |
| CHEMBL155580 | — | — | 1 | 9.80 |
| CHEMBL154590 | — | — | 1 | 9.10 |
| CHEMBL157821 | — | — | 1 | 9.08 |
| CHEMBL154947 | — | — | 1 | 8.58 |
| CHEMBL6619 | — | — | 1 | 8.35 |
| CHEMBL155591 | — | — | 1 | 7.96 |
| CHEMBL156843 | — | — | 1 | 7.75 |
| CHEMBL352015 | — | — | 1 | 6.89 |
| CHEMBL347130 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157972 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL155580 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL154590 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL157821 | — | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL154947 | — | EC50 | = | 2.65 | nM | 8.58 |
| CHEMBL6619 | — | EC50 | = | 4.51 | nM | 8.35 |
| CHEMBL155591 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL156843 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL352015 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL347130 | — | EC50 | > | 1000.0 | nM | - |