Assay Detail
Functional
CHEMBL714333
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Anti-HIV-1 activity against Y181C strain, in MT-4 cells by the MTT method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.79 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.40 |
| CHEMBL136862 | — | — | 1 | 7.29 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 7.00 |
| CHEMBL338047 | — | — | 1 | 7.00 |
| CHEMBL344591 | — | — | 1 | 6.80 |
| CHEMBL137117 | — | — | 1 | 6.80 |
| CHEMBL319139 | — | — | 1 | 6.75 |
| CHEMBL137851 | — | — | 1 | 6.50 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.60 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL136862 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL338047 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL344591 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL137117 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL319139 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL137851 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL57 | NEVIRAPINE | IC50 | > | 10000.0 | nM | - |