Assay Detail
Binding
CHEMBL714368
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pA2 value for human Melanocortin-4 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.43 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161313 | — | — | 1 | 9.80 |
| CHEMBL1161322 | — | — | 1 | 9.30 |
| CHEMBL2096742 | — | — | 1 | 9.10 |
| CHEMBL1161323 | — | — | 1 | 8.90 |
| CHEMBL2372588 | — | — | 1 | 8.60 |
| CHEMBL1161318 | — | — | 1 | 8.40 |
| CHEMBL2372589 | — | — | 1 | 8.00 |
| CHEMBL1161316 | — | — | 1 | 8.00 |
| CHEMBL1161321 | — | — | 1 | 7.70 |
| CHEMBL1161320 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161313 | — | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL1161322 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL2096742 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL1161323 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL2372588 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL1161318 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL2372589 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL1161316 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL1161321 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL1161320 | — | Kd | = | 316.23 | nM | 6.50 |