Assay Detail
Binding
CHEMBL714426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.95 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279356 | — | — | 1 | 6.46 |
| CHEMBL422742 | — | — | 1 | 6.31 |
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 6.29 |
| CHEMBL169625 | — | — | 1 | 6.28 |
| CHEMBL169150 | — | — | 1 | 6.26 |
| CHEMBL168472 | — | — | 1 | 6.25 |
| CHEMBL12378 | — | — | 1 | 6.16 |
| CHEMBL416736 | — | — | 1 | 6.00 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.00 |
| CHEMBL169019 | — | — | 1 | 5.64 |
| CHEMBL168218 | — | — | 1 | 5.64 |
| CHEMBL277014 | — | — | 1 | 5.57 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.26 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279356 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL422742 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL20835 | ACECLIDINE | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL169625 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL169150 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL168472 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL12378 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL416736 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL169019 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL168218 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL277014 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL14 | CARBACHOL | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL550 | PILOCARPINE | IC50 | = | 7600.0 | nM | 5.12 |