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Assay Detail

CHEMBL714510

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to inhibit antigen-induced release of histamine (AIR) by 50% from passively sensitized rat mast cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

[1,4]Benzoxazine-2,3-diones as antiallergic agents.
Loev B, Jones H, Brown RE, Huang FC, Khandwala A, Leibowitz MJ, Sonnino-Goldman P.
J Med Chem (1985) 28 : 24 -27
PubMed 2578192 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.95 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL91769 1 6.10
CHEMBL88722 1 5.92
CHEMBL327993 1 5.52
CHEMBL90481 1 5.47
CHEMBL74 CROMOLYN SODIUM 4.0 1 5.35
CHEMBL91012 1 5.16
CHEMBL91599 1 5.00
CHEMBL88767 1 5.00
CHEMBL88750 1 5.00
CHEMBL91768 1 4.82
CHEMBL327171 1 4.82
CHEMBL91878 1 4.80
CHEMBL88801 1 4.55
CHEMBL90482 1 4.52
CHEMBL90921 1 4.50
CHEMBL91651 1 4.38
CHEMBL90880 1 4.22
CHEMBL433150 1 4.00
CHEMBL92316 1 -
CHEMBL91670 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL91769 IC50 = 800.0 nM 6.10
CHEMBL88722 IC50 = 1200.0 nM 5.92
CHEMBL327993 IC50 = 3000.0 nM 5.52
CHEMBL90481 IC50 = 3400.0 nM 5.47
CHEMBL74 CROMOLYN SODIUM IC50 = 4500.0 nM 5.35
CHEMBL91012 IC50 = 7000.0 nM 5.16
CHEMBL91599 IC50 = 10000.0 nM 5.00
CHEMBL88767 IC50 = 10000.0 nM 5.00
CHEMBL88750 IC50 = 10000.0 nM 5.00
CHEMBL91768 IC50 = 15000.0 nM 4.82
CHEMBL327171 IC50 = 15000.0 nM 4.82
CHEMBL91878 IC50 = 16000.0 nM 4.80
CHEMBL88801 IC50 = 28000.0 nM 4.55
CHEMBL90482 IC50 = 30000.0 nM 4.52
CHEMBL90921 IC50 = 32000.0 nM 4.50
CHEMBL91651 IC50 = 42000.0 nM 4.38
CHEMBL90880 IC50 = 60000.0 nM 4.22
CHEMBL433150 IC50 = 100000.0 nM 4.00
CHEMBL92316 IC50 = 170000.0 nM -
CHEMBL91670 IC50 < 100000.0 nM -