Assay Detail
Binding
CHEMBL714516
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Inhibition of Matrix metalloprotease-9
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.08 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.70 |
| CHEMBL317508 | — | — | 1 | 9.22 |
| CHEMBL317132 | — | — | 1 | 9.22 |
| CHEMBL323371 | — | — | 1 | 9.00 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.80 |
| CHEMBL100584 | — | — | 1 | 8.44 |
| CHEMBL101121 | — | — | 1 | 8.30 |
| CHEMBL103442 | — | — | 1 | 7.80 |
| CHEMBL100805 | — | — | 1 | 7.60 |
| CHEMBL102459 | — | — | 1 | 7.48 |
| CHEMBL323148 | — | — | 1 | 6.70 |
| CHEMBL318795 | — | — | 1 | 6.66 |
| CHEMBL38851 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL317508 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL317132 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL323371 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL100584 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL101121 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL103442 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL100805 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL102459 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL323148 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL318795 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL38851 | — | IC50 | = | 655.0 | nM | 6.18 |