Assay Detail
Binding
CHEMBL714517
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Inhibition of human matrix metalloprotease 9
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.85 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 8.37 |
| CHEMBL176602 | — | — | 1 | 7.69 |
| CHEMBL355752 | — | — | 1 | 7.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL176602 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL355752 | — | IC50 | = | 32.5 | nM | 7.49 |