Assay Detail
Binding
CHEMBL714518
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Inhibition of Matrix metalloprotease-9
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of potent, achiral matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.08 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115727 | — | — | 1 | 8.57 |
| CHEMBL333729 | — | — | 1 | 8.41 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.37 |
| CHEMBL118744 | — | — | 1 | 8.33 |
| CHEMBL118848 | — | — | 1 | 7.81 |
| CHEMBL334107 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115727 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL333729 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL118744 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL118848 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL334107 | — | IC50 | = | 101.0 | nM | 7.00 |