Assay Detail
Binding
CHEMBL714550
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In vitro inhibition of Matrix metalloprotein 1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.19 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96637 | — | — | 1 | 8.05 |
| CHEMBL94363 | — | — | 1 | 8.00 |
| CHEMBL316298 | — | — | 1 | 7.21 |
| CHEMBL94357 | — | — | 1 | 6.59 |
| CHEMBL94643 | — | — | 1 | 6.48 |
| CHEMBL316928 | — | — | 1 | 6.32 |
| CHEMBL317624 | — | — | 1 | 6.06 |
| CHEMBL98061 | — | — | 1 | 6.03 |
| CHEMBL92927 | — | — | 1 | 5.94 |
| CHEMBL96396 | — | — | 1 | 5.72 |
| CHEMBL321556 | — | — | 1 | 5.72 |
| CHEMBL96417 | — | — | 1 | 5.61 |
| CHEMBL328751 | — | — | 1 | 5.53 |
| CHEMBL94948 | — | — | 1 | 5.39 |
| CHEMBL94518 | — | — | 1 | 5.31 |
| CHEMBL96636 | — | — | 1 | 5.00 |
| CHEMBL94386 | — | — | 1 | - |
| CHEMBL431057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96637 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL94363 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL316298 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL94357 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL94643 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL316928 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL317624 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL98061 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL92927 | — | IC50 | = | 1156.0 | nM | 5.94 |
| CHEMBL96396 | — | IC50 | = | 1908.0 | nM | 5.72 |
| CHEMBL321556 | — | IC50 | = | 1895.0 | nM | 5.72 |
| CHEMBL96417 | — | IC50 | = | 2471.0 | nM | 5.61 |
| CHEMBL328751 | — | IC50 | = | 2965.0 | nM | 5.53 |
| CHEMBL94948 | — | IC50 | = | 4031.0 | nM | 5.39 |
| CHEMBL94518 | — | IC50 | = | 4948.0 | nM | 5.31 |
| CHEMBL96636 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL94386 | — | IC50 | ~ | 10000.0 | nM | - |
| CHEMBL431057 | — | IC50 | > | 10000.0 | nM | - |