Assay Detail
Binding
CHEMBL714553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay
47
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.92 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 9.11 |
| CHEMBL76757 | — | — | 1 | 8.54 |
| CHEMBL308264 | — | — | 1 | 8.44 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.24 |
| CHEMBL76222 | REBIMASTAT | 2.0 | 1 | 7.60 |
| CHEMBL75154 | — | — | 1 | 7.36 |
| CHEMBL75487 | — | — | 1 | 7.11 |
| CHEMBL76043 | — | — | 1 | 7.09 |
| CHEMBL75302 | — | — | 1 | 7.05 |
| CHEMBL75618 | — | — | 1 | 6.62 |
| CHEMBL75139 | — | — | 1 | 6.55 |
| CHEMBL309053 | — | — | 1 | 6.09 |
| CHEMBL311618 | — | — | 1 | 6.00 |
| CHEMBL275654 | — | — | 1 | 5.70 |
| CHEMBL75529 | — | — | 1 | 5.60 |
| CHEMBL73652 | — | — | 1 | 5.60 |
| CHEMBL307413 | — | — | 1 | 5.35 |
| CHEMBL75437 | — | — | 1 | 5.34 |
| CHEMBL75567 | — | — | 1 | 5.28 |
| CHEMBL311141 | — | — | 1 | 5.18 |
| CHEMBL74151 | — | — | 1 | 5.17 |
| CHEMBL3037894 | — | — | 1 | 5.10 |
| CHEMBL75464 | — | — | 1 | 5.08 |
| CHEMBL2115165 | — | — | 2 | 5.05 |
| CHEMBL307372 | — | — | 1 | 5.00 |
| CHEMBL78052 | — | — | 1 | 4.30 |
| CHEMBL2114138 | — | — | 2 | 4.30 |
| CHEMBL306585 | — | — | 1 | 4.30 |
| CHEMBL75114 | — | — | 1 | 4.30 |
| CHEMBL306276 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL76757 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL308264 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL76222 | REBIMASTAT | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL75154 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL75487 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL76043 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL75302 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL75618 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL75139 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL309053 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL311618 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL275654 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL73652 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL75529 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL307413 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL75437 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL75567 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL311141 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL74151 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3037894 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL75464 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2115165 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL307372 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL78052 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2114138 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2114138 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2115165 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL306585 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL75114 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL306276 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL78213 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL261932 | TANOMASTAT | IC50 | > | 5000.0 | nM | - |
| CHEMBL73928 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL74812 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL78145 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL309329 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL306301 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL73866 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL306050 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL77907 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL75189 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL307915 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL75164 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL77874 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL74365 | — | IC50 | > | 50000.0 | nM | - |