Assay Detail
Binding
CHEMBL714556
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Inhibitory activity against human matrix metalloprotease-1 (MMP-1)
44
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.13 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 8.60 |
| CHEMBL2111753 | — | — | 2 | 7.23 |
| CHEMBL114815 | — | — | 1 | 7.19 |
| CHEMBL114378 | — | — | 1 | 7.00 |
| CHEMBL432834 | — | — | 1 | 6.96 |
| CHEMBL4524116 | — | — | 1 | 6.82 |
| CHEMBL114272 | — | — | 1 | 6.77 |
| CHEMBL4524115 | — | — | 1 | 6.75 |
| CHEMBL325678 | — | — | 1 | 6.75 |
| CHEMBL113778 | — | — | 1 | 6.70 |
| CHEMBL326369 | — | — | 1 | 6.58 |
| CHEMBL115283 | — | — | 1 | 6.55 |
| CHEMBL2111754 | — | — | 1 | 6.54 |
| CHEMBL321257 | — | — | 1 | 6.50 |
| CHEMBL116287 | — | — | 1 | 6.48 |
| CHEMBL111856 | — | — | 1 | 6.38 |
| CHEMBL114148 | — | — | 1 | 6.31 |
| CHEMBL114884 | — | — | 1 | 6.30 |
| CHEMBL115223 | — | — | 1 | 6.26 |
| CHEMBL112609 | — | — | 1 | 6.26 |
| CHEMBL116904 | — | — | 1 | 6.26 |
| CHEMBL116219 | — | — | 1 | 6.13 |
| CHEMBL112470 | — | — | 1 | 6.12 |
| CHEMBL114906 | — | — | 1 | 6.11 |
| CHEMBL324806 | — | — | 1 | 6.06 |
| CHEMBL116348 | — | — | 1 | 6.05 |
| CHEMBL114831 | — | — | 1 | 5.92 |
| CHEMBL323612 | — | — | 1 | 5.92 |
| CHEMBL116237 | — | — | 1 | 5.85 |
| CHEMBL4524117 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2111753 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL114815 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL114378 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL432834 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4524116 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL114272 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL325678 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4524115 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL113778 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL326369 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL115283 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2111754 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL321257 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL116287 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2111753 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL111856 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL114148 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL114884 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL112609 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL115223 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL116904 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL116219 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL112470 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL114906 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL324806 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL116348 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL323612 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL114831 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL116237 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4524117 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL115168 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL113705 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL116067 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL325903 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL117375 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL324555 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL324615 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL112374 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL114528 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL324578 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL115877 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL114158 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL115666 | — | IC50 | = | 12000.0 | nM | 4.92 |