Assay Detail
Binding
CHEMBL714557
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Inhibition of matrix metalloprotease-1 (MMP-1)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.38 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.22 |
| CHEMBL147489 | — | — | 1 | 7.39 |
| CHEMBL358539 | — | — | 1 | 7.06 |
| CHEMBL148214 | — | — | 1 | 6.91 |
| CHEMBL147882 | — | — | 1 | 6.82 |
| CHEMBL147881 | — | — | 1 | 6.34 |
| CHEMBL146718 | — | — | 1 | 6.33 |
| CHEMBL148171 | — | — | 1 | 6.22 |
| CHEMBL146289 | — | — | 1 | 5.20 |
| CHEMBL148406 | — | — | 1 | 4.88 |
| CHEMBL356124 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL147489 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL358539 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL148214 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL147882 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL147881 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL146718 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL148171 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL146289 | — | IC50 | = | 6319.0 | nM | 5.20 |
| CHEMBL148406 | — | IC50 | = | 13190.0 | nM | 4.88 |
| CHEMBL356124 | — | IC50 | = | 15020.0 | nM | 4.82 |