Assay Detail
Binding
CHEMBL714559
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Inhibitory activity against matrix metalloprotease 1 (MMP-1).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.51 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288670 | — | — | 1 | 7.41 |
| CHEMBL34808 | — | — | 1 | 7.34 |
| CHEMBL38352 | — | — | 1 | 7.19 |
| CHEMBL285546 | — | — | 1 | 7.12 |
| CHEMBL287820 | — | — | 1 | 7.11 |
| CHEMBL35433 | — | — | 1 | 7.00 |
| CHEMBL36191 | — | — | 1 | 6.97 |
| CHEMBL34418 | — | — | 1 | 6.96 |
| CHEMBL429336 | — | — | 1 | 6.94 |
| CHEMBL286848 | — | — | 1 | 6.94 |
| CHEMBL37788 | — | — | 1 | 6.87 |
| CHEMBL289411 | — | — | 1 | 6.82 |
| CHEMBL290952 | — | — | 1 | 6.82 |
| CHEMBL418053 | — | — | 1 | 6.76 |
| CHEMBL287823 | — | — | 1 | 6.76 |
| CHEMBL36021 | — | — | 1 | 6.76 |
| CHEMBL35059 | — | — | 1 | 6.75 |
| CHEMBL290948 | — | — | 1 | 6.72 |
| CHEMBL38106 | — | — | 1 | 6.70 |
| CHEMBL37837 | — | — | 1 | 6.65 |
| CHEMBL36999 | — | — | 1 | 6.46 |
| CHEMBL35707 | — | — | 1 | 6.26 |
| CHEMBL288671 | — | — | 1 | 6.07 |
| CHEMBL33980 | — | — | 1 | 6.04 |
| CHEMBL34411 | — | — | 1 | 6.03 |
| CHEMBL35989 | — | — | 1 | 6.02 |
| CHEMBL289222 | — | — | 1 | 6.00 |
| CHEMBL287871 | — | — | 1 | 6.00 |
| CHEMBL38180 | — | — | 1 | 5.74 |
| CHEMBL35606 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288670 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL34808 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL38352 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL285546 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL287820 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL35433 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL36191 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL34418 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL429336 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL286848 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL37788 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL289411 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL290952 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL36021 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL287823 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL418053 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL35059 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL290948 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL38106 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL37837 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL36999 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL35707 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL288671 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL33980 | — | IC50 | = | 913.0 | nM | 6.04 |
| CHEMBL34411 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL35989 | — | IC50 | = | 956.0 | nM | 6.02 |
| CHEMBL289222 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL287871 | — | IC50 | = | 1012.0 | nM | 6.00 |
| CHEMBL38180 | — | IC50 | = | 1805.0 | nM | 5.74 |
| CHEMBL35606 | — | IC50 | = | 1922.0 | nM | 5.72 |
| CHEMBL36309 | — | IC50 | = | 1911.0 | nM | 5.72 |
| CHEMBL417144 | — | IC50 | = | 2333.0 | nM | 5.63 |
| CHEMBL34660 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL289604 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL34666 | — | IC50 | > | 1000.0 | nM | - |