Assay Detail
Binding
CHEMBL714560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Matrix metalloprotease-1
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.09 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318860 | — | — | 1 | 8.64 |
| CHEMBL318484 | — | — | 1 | 8.24 |
| CHEMBL98770 | — | — | 1 | 8.17 |
| CHEMBL95305 | — | — | 1 | 7.58 |
| CHEMBL99103 | — | — | 1 | 7.55 |
| CHEMBL99120 | — | — | 1 | 6.85 |
| CHEMBL318005 | — | — | 1 | 6.64 |
| CHEMBL99547 | — | — | 1 | 6.50 |
| CHEMBL95718 | — | — | 1 | 5.64 |
| CHEMBL98304 | — | — | 1 | 5.04 |
| CHEMBL329232 | — | — | 1 | - |
| CHEMBL316725 | — | — | 1 | - |
| CHEMBL99109 | — | — | 1 | - |
| CHEMBL99318 | — | — | 1 | - |
| CHEMBL99283 | — | — | 1 | - |
| CHEMBL329302 | — | — | 1 | - |
| CHEMBL421009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318860 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL318484 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL98770 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL95305 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL99103 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL99120 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL318005 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL99547 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL95718 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL98304 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL329232 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL316725 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL99109 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL99318 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL99283 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL329302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421009 | — | IC50 | > | 10000.0 | nM | - |