Assay Detail
Functional
CHEMBL714598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.16 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349850 | — | — | 1 | 8.15 |
| CHEMBL349515 | — | — | 1 | 8.10 |
| CHEMBL433710 | — | — | 1 | 7.85 |
| CHEMBL423101 | — | — | 1 | 7.85 |
| CHEMBL338594 | — | — | 1 | 7.80 |
| CHEMBL164857 | — | — | 1 | 7.68 |
| CHEMBL351161 | — | — | 1 | 7.47 |
| CHEMBL349886 | — | — | 1 | 7.43 |
| CHEMBL349887 | — | — | 1 | 7.41 |
| CHEMBL423619 | — | — | 1 | 7.40 |
| CHEMBL423250 | — | — | 1 | 7.36 |
| CHEMBL353239 | — | — | 1 | 7.36 |
| CHEMBL351088 | — | — | 1 | 7.36 |
| CHEMBL406764 | — | — | 1 | 7.32 |
| CHEMBL166328 | — | — | 1 | 7.15 |
| CHEMBL164884 | — | — | 1 | 7.03 |
| CHEMBL164671 | — | — | 1 | 7.01 |
| CHEMBL352063 | — | — | 1 | 6.96 |
| CHEMBL352457 | — | — | 1 | 6.85 |
| CHEMBL352677 | — | — | 1 | 6.84 |
| CHEMBL422027 | — | — | 1 | 6.82 |
| CHEMBL162493 | — | — | 1 | 6.82 |
| CHEMBL164969 | — | — | 1 | 6.70 |
| CHEMBL167780 | — | — | 1 | 6.68 |
| CHEMBL351400 | — | — | 1 | 6.44 |
| CHEMBL165746 | — | — | 1 | 6.40 |
| CHEMBL351705 | — | — | 1 | 6.31 |
| CHEMBL349427 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349850 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL349515 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL433710 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL423101 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL338594 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL164857 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL351161 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL349886 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL349887 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL423619 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL423250 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL353239 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL351088 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL406764 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL166328 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL164884 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL164671 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL352063 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL352457 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL352677 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL422027 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL162493 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL164969 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL167780 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL351400 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL165746 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL351705 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL349427 | — | EC50 | = | 1300.0 | nM | 5.89 |