Assay Detail
Functional
CHEMBL714605
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Effective concentration for intracellular cAMP accumulation in L-cells expressing Melanocortin 4 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.74 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | — | 1 | 10.40 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.14 |
| CHEMBL2115441 | — | — | 1 | 8.60 |
| CHEMBL410217 | — | — | 1 | 8.54 |
| CHEMBL413260 | — | — | 1 | 8.47 |
| CHEMBL217584 | — | — | 1 | 8.22 |
| CHEMBL3350396 | — | — | 1 | 7.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.72 | nM | 9.14 |
| CHEMBL2115441 | — | EC50 | = | 2.52 | nM | 8.60 |
| CHEMBL410217 | — | EC50 | = | 2.92 | nM | 8.54 |
| CHEMBL413260 | — | EC50 | = | 3.38 | nM | 8.47 |
| CHEMBL217584 | — | EC50 | = | 6.08 | nM | 8.22 |
| CHEMBL3350396 | — | EC50 | = | 14.6 | nM | 7.84 |