Assay Detail
Functional
CHEMBL714614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.99 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40086 | — | — | 1 | 6.32 |
| CHEMBL544508 | — | — | 1 | 5.40 |
| CHEMBL540015 | — | — | 1 | 5.21 |
| CHEMBL543568 | — | — | 1 | 4.62 |
| CHEMBL552836 | — | — | 1 | 4.48 |
| CHEMBL542862 | — | — | 1 | 4.46 |
| CHEMBL543811 | — | — | 1 | 4.43 |
| CHEMBL552837 | — | — | 1 | - |
| CHEMBL538487 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40086 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL544508 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL540015 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL543568 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL552836 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL542862 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL543811 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL552837 | — | EC50 | = | 160000.0 | nM | - |
| CHEMBL538487 | — | EC50 | = | 950000.0 | nM | - |