Assay Detail
Binding
CHEMBL714627
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Inhibition of recombinant human matrix metalloprotease-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of selective azasugar-based TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.73 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291264 | — | — | 1 | 7.05 |
| CHEMBL43087 | — | — | 1 | 6.89 |
| CHEMBL41821 | — | — | 1 | 6.26 |
| CHEMBL288843 | — | — | 1 | - |
| CHEMBL288664 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291264 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL43087 | — | Ki | = | 128.22 | nM | 6.89 |
| CHEMBL41821 | — | Ki | = | 552.4 | nM | 6.26 |
| CHEMBL288843 | — | Ki | > | 850.0 | nM | - |
| CHEMBL288664 | — | Ki | > | 850.0 | nM | - |