Assay Detail
Binding
CHEMBL714632
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Inhibition of Matrix Metalloprotease-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: identification of novel inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.07 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29897 | — | — | 1 | 7.52 |
| CHEMBL69323 | — | — | 1 | 7.46 |
| CHEMBL30034 | — | — | 1 | 7.19 |
| CHEMBL305024 | — | — | 1 | 6.66 |
| CHEMBL69194 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29897 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL69323 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL30034 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL305024 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL69194 | — | IC50 | = | 319.0 | nM | 6.50 |