Assay Detail
Binding
CHEMBL714637
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Inhibition of matrix metalloprotease-1 (MMP-1)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.78 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 7.82 |
| CHEMBL90978 | — | — | 1 | 7.66 |
| CHEMBL327621 | — | — | 1 | 7.35 |
| CHEMBL539787 | — | — | 1 | 7.04 |
| CHEMBL327442 | — | — | 1 | 6.94 |
| CHEMBL329558 | — | — | 1 | 6.89 |
| CHEMBL328255 | — | — | 1 | 6.60 |
| CHEMBL310649 | — | — | 1 | 6.51 |
| CHEMBL313168 | — | — | 1 | 6.51 |
| CHEMBL419868 | — | — | 1 | 6.35 |
| CHEMBL310655 | — | — | 1 | 6.21 |
| CHEMBL88559 | — | — | 1 | 6.16 |
| CHEMBL538028 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL90978 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL327621 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL539787 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL327442 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL329558 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL328255 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL310649 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL313168 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL419868 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL310655 | — | IC50 | = | 618.0 | nM | 6.21 |
| CHEMBL88559 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL538028 | — | IC50 | = | 703.0 | nM | 6.15 |