Assay Detail
Binding
CHEMBL714722
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In vitro inhibition of Matrix metalloprotease-1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.49 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 7.82 |
| CHEMBL69268 | — | — | 1 | 7.75 |
| CHEMBL419995 | — | — | 1 | 7.13 |
| CHEMBL68271 | — | — | 1 | 6.99 |
| CHEMBL71725 | — | — | 1 | 6.91 |
| CHEMBL307079 | — | — | 1 | 6.88 |
| CHEMBL70176 | — | — | 1 | 6.84 |
| CHEMBL303666 | — | — | 1 | 6.71 |
| CHEMBL70957 | — | — | 1 | 6.54 |
| CHEMBL68196 | — | — | 1 | 6.42 |
| CHEMBL304730 | — | — | 1 | 6.27 |
| CHEMBL71007 | — | — | 1 | 6.13 |
| CHEMBL68542 | — | — | 1 | 6.13 |
| CHEMBL71309 | — | — | 1 | 5.98 |
| CHEMBL71686 | — | — | 1 | 5.88 |
| CHEMBL71645 | — | — | 1 | 5.64 |
| CHEMBL68212 | — | — | 1 | 5.49 |
| CHEMBL71436 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL69268 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL419995 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL68271 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL71725 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL307079 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL70176 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL303666 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL70957 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL68196 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL304730 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL71007 | — | IC50 | = | 747.0 | nM | 6.13 |
| CHEMBL68542 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL71309 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL71686 | — | IC50 | = | 1314.0 | nM | 5.88 |
| CHEMBL71645 | — | IC50 | = | 2268.0 | nM | 5.64 |
| CHEMBL68212 | — | IC50 | = | 3245.0 | nM | 5.49 |
| CHEMBL71436 | — | IC50 | = | 4640.0 | nM | 5.33 |