Assay Detail
Binding
CHEMBL714733
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Inhibition of Matrix metalloprotease-1 (MMP-1)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.44 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32310 | — | — | 1 | 6.96 |
| CHEMBL32325 | — | — | 1 | 6.61 |
| CHEMBL32596 | — | — | 1 | 6.36 |
| CHEMBL34085 | — | — | 1 | 6.30 |
| CHEMBL32631 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32310 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL32325 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL32596 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL34085 | — | Ki | = | 496.0 | nM | 6.30 |
| CHEMBL32631 | — | Ki | = | 1068.0 | nM | 5.97 |