Assay Detail
Binding
CHEMBL714751
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Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.27 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281496 | — | — | 1 | 8.00 |
| CHEMBL28629 | — | — | 1 | 8.00 |
| CHEMBL26779 | — | — | 1 | 7.96 |
| CHEMBL25903 | — | — | 1 | 7.92 |
| CHEMBL26150 | — | — | 1 | 7.92 |
| CHEMBL25905 | — | — | 1 | 7.89 |
| CHEMBL29743 | — | — | 1 | 7.86 |
| CHEMBL281326 | — | — | 1 | 7.82 |
| CHEMBL418382 | — | — | 1 | 7.77 |
| CHEMBL284024 | — | — | 1 | 7.72 |
| CHEMBL283255 | — | — | 1 | 7.70 |
| CHEMBL27007 | — | — | 1 | 7.68 |
| CHEMBL26678 | — | — | 1 | 7.62 |
| CHEMBL430724 | — | — | 1 | 7.62 |
| CHEMBL29631 | — | — | 1 | 7.58 |
| CHEMBL283253 | — | — | 1 | 7.57 |
| CHEMBL25731 | — | — | 1 | 7.55 |
| CHEMBL439727 | — | — | 1 | 7.54 |
| CHEMBL285343 | — | — | 1 | 7.39 |
| CHEMBL27415 | — | — | 1 | 7.39 |
| CHEMBL286948 | — | — | 1 | 7.35 |
| CHEMBL27536 | — | — | 1 | 7.35 |
| CHEMBL26081 | — | — | 1 | 7.32 |
| CHEMBL25867 | — | — | 1 | 7.29 |
| CHEMBL27257 | — | — | 1 | 7.23 |
| CHEMBL282156 | — | — | 1 | 7.23 |
| CHEMBL284676 | — | — | 1 | 7.20 |
| CHEMBL283438 | — | — | 1 | 7.19 |
| CHEMBL287400 | — | — | 1 | 7.17 |
| CHEMBL26039 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281496 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL28629 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL26779 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL25903 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL26150 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL25905 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL29743 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL281326 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL418382 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL284024 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL283255 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL27007 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL26678 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL430724 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL29631 | — | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL283253 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL25731 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL439727 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL285343 | — | IC50 | = | 40.9 | nM | 7.39 |
| CHEMBL27415 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL27536 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL286948 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL26081 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL25867 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL27257 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL282156 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL284676 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL283438 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL287400 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL26039 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL26686 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL282365 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL283693 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL27191 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL28584 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL430925 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL28168 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL30052 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL27128 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL431503 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL26369 | — | IC50 | = | 632.0 | nM | 6.20 |
| CHEMBL281235 | — | IC50 | = | 708.0 | nM | 6.15 |
| CHEMBL25972 | — | IC50 | = | 708.0 | nM | 6.15 |