Assay Detail
Binding
CHEMBL714993
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Inhibitory activity against matrix metalloprotease-2 (MMP2)
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.51 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126461 | — | — | 1 | 10.22 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.30 |
| CHEMBL127138 | — | — | 1 | 8.77 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.74 |
| CHEMBL125104 | — | — | 1 | 8.55 |
| CHEMBL337946 | — | — | 1 | 8.30 |
| CHEMBL338877 | — | — | 1 | 8.05 |
| CHEMBL126711 | — | — | 1 | 7.89 |
| CHEMBL340771 | — | — | 1 | 7.89 |
| CHEMBL339610 | — | — | 1 | 7.85 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.82 |
| CHEMBL126380 | — | — | 3 | 7.75 |
| CHEMBL127168 | — | — | 1 | 7.70 |
| CHEMBL127035 | — | — | 1 | 7.70 |
| CHEMBL126977 | — | — | 1 | 7.62 |
| CHEMBL127867 | — | — | 1 | 7.60 |
| CHEMBL126923 | — | — | 1 | 7.34 |
| CHEMBL123503 | — | — | 1 | 7.21 |
| CHEMBL340455 | — | — | 1 | 7.14 |
| CHEMBL337986 | — | — | 1 | 7.12 |
| CHEMBL127559 | — | — | 1 | 7.12 |
| CHEMBL341249 | — | — | 1 | 7.08 |
| CHEMBL339137 | — | — | 1 | 6.97 |
| CHEMBL340345 | — | — | 1 | 6.89 |
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 6.81 |
| CHEMBL125901 | — | — | 1 | 6.75 |
| CHEMBL127787 | — | — | 1 | 6.42 |
| CHEMBL126712 | — | — | 1 | 6.24 |
| CHEMBL339588 | — | — | 1 | 6.13 |
| CHEMBL125138 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126461 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL127138 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL125104 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL337946 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL338877 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL126711 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL340771 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL339610 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL126380 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL127035 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL127168 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL126977 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL127867 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL126923 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL123503 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL126380 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL340455 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL127559 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL337986 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL341249 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL339137 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL340345 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL115653 | CIPEMASTAT | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL125901 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL127787 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL126712 | — | IC50 | = | 572.0 | nM | 6.24 |
| CHEMBL339588 | — | IC50 | = | 743.0 | nM | 6.13 |
| CHEMBL125138 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL126380 | — | IC50 | = | 849.0 | nM | 6.07 |
| CHEMBL339315 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL125302 | — | IC50 | > | 8.0 | nM | - |