Assay Detail
Functional
CHEMBL715136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to block replication of HIV-1 virus in mock infected MT-4 cells
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL108078 | — | — | 1 | 7.92 |
| CHEMBL321236 | — | — | 1 | 7.75 |
| CHEMBL325143 | — | — | 1 | 7.58 |
| CHEMBL66350 | — | — | 1 | 7.58 |
| CHEMBL321650 | — | — | 1 | 7.54 |
| CHEMBL293498 | — | — | 1 | 7.41 |
| CHEMBL66434 | — | — | 1 | 7.22 |
| CHEMBL46961 | — | — | 1 | 7.01 |
| CHEMBL107217 | DITIOCARB SODIUM | 2.0 | 1 | 6.86 |
| CHEMBL82396 | — | — | 1 | 6.75 |
| CHEMBL110818 | — | — | 1 | 6.42 |
| CHEMBL349294 | — | — | 1 | 6.41 |
| CHEMBL111610 | — | — | 1 | 6.38 |
| CHEMBL67451 | — | — | 1 | 5.77 |
| CHEMBL323747 | — | — | 1 | 5.66 |
| CHEMBL168006 | — | — | 1 | 5.38 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.26 |
| CHEMBL66404 | — | — | 1 | 5.01 |
| CHEMBL326446 | — | — | 1 | 5.00 |
| CHEMBL65801 | — | — | 1 | 4.82 |
| CHEMBL66377 | — | — | 1 | 4.22 |
| CHEMBL108706 | — | — | 1 | - |
| CHEMBL107553 | — | — | 1 | - |
| CHEMBL107557 | — | — | 1 | - |
| CHEMBL111177 | — | — | 1 | - |
| CHEMBL108382 | — | — | 1 | - |
| CHEMBL108885 | — | — | 1 | - |
| CHEMBL326198 | — | — | 1 | - |
| CHEMBL325566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL108078 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL321236 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL325143 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL66350 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL321650 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL293498 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL66434 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL46961 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL107217 | DITIOCARB SODIUM | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL82396 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL110818 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL349294 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL111610 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL67451 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL323747 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL168006 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL66404 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL326446 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL65801 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL66377 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL109038 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109025 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL322764 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL323215 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL108314 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL109940 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL108589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421226 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL110156 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL108864 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL108092 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL321639 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL108890 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL322808 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL431439 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL323952 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL320985 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL325566 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL326198 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL108885 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL108382 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL111177 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL107557 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL107553 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL108706 | — | IC50 | > | 2000.0 | nM | - |