Assay Detail
Binding
CHEMBL715218
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Inhibition of Matrix metalloprotease-9 activity
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278872 | — | — | 1 | 8.70 |
| CHEMBL18614 | — | — | 1 | 7.96 |
| CHEMBL278060 | — | — | 1 | 7.82 |
| CHEMBL273764 | — | — | 1 | 7.68 |
| CHEMBL19278 | — | — | 1 | 7.55 |
| CHEMBL18667 | — | — | 1 | 6.78 |
| CHEMBL18649 | — | — | 1 | 6.63 |
| CHEMBL19005 | — | — | 1 | 6.52 |
| CHEMBL416173 | — | — | 1 | 6.41 |
| CHEMBL18895 | — | — | 1 | 6.41 |
| CHEMBL19279 | — | — | 1 | 6.34 |
| CHEMBL18943 | — | — | 1 | 6.32 |
| CHEMBL19269 | — | — | 1 | 6.19 |
| CHEMBL19371 | — | — | 1 | 6.10 |
| CHEMBL418737 | — | — | 1 | 6.07 |
| CHEMBL276275 | — | — | 1 | 5.92 |
| CHEMBL277206 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278872 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL18614 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL278060 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL273764 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL19278 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL18667 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL18649 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL19005 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL416173 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL18895 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL19279 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL18943 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL19269 | — | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL19371 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL418737 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL276275 | — | IC50 | = | 1205.0 | nM | 5.92 |
| CHEMBL277206 | — | IC50 | = | 2827.0 | nM | 5.55 |