Assay Detail
Binding
CHEMBL715226
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Inhibition of Matrix metalloprotease-9
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.28 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18614 | — | — | 1 | 7.96 |
| CHEMBL278060 | — | — | 1 | 7.82 |
| CHEMBL273764 | — | — | 1 | 7.68 |
| CHEMBL19005 | — | — | 1 | 6.52 |
| CHEMBL416173 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18614 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL278060 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL273764 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL19005 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL416173 | — | IC50 | = | 389.0 | nM | 6.41 |