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Assay Detail

CHEMBL715233

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Matrix metalloprotease-9 (concentration required for 50% inhibition of enzyme activity)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Matrix metalloproteinase-9 (CHEMBL321)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Homology modeling of gelatinase catalytic domains and docking simulations of novel sulfonamide inhibitors.
Kiyama R, Tamura Y, Watanabe F, Tsuzuki H, Ohtani M, Yodo M.
J Med Chem (1999) 42 : 1723 -1738
PubMed 10346925 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.76 8.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49413 1 8.36
CHEMBL47971 1 8.14
CHEMBL296327 1 8.09
CHEMBL297792 S-3304 1.0 1 8.02
CHEMBL48368 1 7.92
CHEMBL298699 1 7.62
CHEMBL288750 1 7.14
CHEMBL50445 1 6.68
CHEMBL295861 1 6.68
CHEMBL291213 1 6.58
CHEMBL49186 1 6.47
CHEMBL48039 1 6.06
CHEMBL45906 1 5.77
CHEMBL297793 1 5.72
CHEMBL49499 1 5.70
CHEMBL296817 1 5.64
CHEMBL50437 1 5.57
CHEMBL49411 1 5.57
CHEMBL291194 1 -
CHEMBL49185 1 -
CHEMBL49671 1 -
CHEMBL298327 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49413 IC50 = 4.4 nM 8.36
CHEMBL47971 IC50 = 7.3 nM 8.14
CHEMBL296327 IC50 = 8.2 nM 8.09
CHEMBL297792 S-3304 IC50 = 9.6 nM 8.02
CHEMBL48368 IC50 = 12.0 nM 7.92
CHEMBL298699 IC50 = 24.0 nM 7.62
CHEMBL288750 IC50 = 72.0 nM 7.14
CHEMBL50445 IC50 = 210.0 nM 6.68
CHEMBL295861 IC50 = 210.0 nM 6.68
CHEMBL291213 IC50 = 260.0 nM 6.58
CHEMBL49186 IC50 = 340.0 nM 6.47
CHEMBL48039 IC50 = 870.0 nM 6.06
CHEMBL45906 IC50 = 1700.0 nM 5.77
CHEMBL297793 IC50 = 1900.0 nM 5.72
CHEMBL49499 IC50 = 2000.0 nM 5.70
CHEMBL296817 IC50 = 2300.0 nM 5.64
CHEMBL50437 IC50 = 2700.0 nM 5.57
CHEMBL49411 IC50 = 2700.0 nM 5.57
CHEMBL291194 IC50 > 20000.0 nM -
CHEMBL49185 IC50 > 20000.0 nM -
CHEMBL49671 IC50 > 20000.0 nM -
CHEMBL298327 IC50 > 20000.0 nM -