Assay Detail
Functional
CHEMBL715327
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Effective concentration required to protect MT-4 cells against cytopathogenicity of HIV-1 LAI
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.34 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.70 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.15 |
| CHEMBL606941 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL991 | STAVUDINE | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL606941 | — | EC50 | = | 6900.0 | nM | 5.16 |