Assay Detail
Binding
CHEMBL715364
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Activity against Matrix metalloprotease-1 (MMP-1).
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.16 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279078 | — | — | 1 | 9.52 |
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 9.40 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.82 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.70 |
| CHEMBL19932 | — | — | 1 | 8.54 |
| CHEMBL16520 | RO-319790 | — | 1 | 8.52 |
| CHEMBL19843 | — | — | 1 | 8.52 |
| CHEMBL433816 | — | — | 1 | 8.46 |
| CHEMBL281371 | — | — | 1 | 8.27 |
| CHEMBL279964 | — | — | 1 | 7.82 |
| CHEMBL20154 | — | — | 1 | 7.68 |
| CHEMBL432842 | — | — | 1 | 7.05 |
| CHEMBL433426 | — | — | 1 | 7.05 |
| CHEMBL19623 | — | — | 1 | 7.04 |
| CHEMBL20043 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279078 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL279786 | BATIMASTAT | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL19932 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL16520 | RO-319790 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL19843 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL433816 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL281371 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL279964 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL20154 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL432842 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL433426 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL19623 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL20043 | — | IC50 | = | 93.0 | nM | 7.03 |