Assay Detail
Binding
CHEMBL715368
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In vitro inhibitory activity against matrix metalloprotease-1 (MMP-1)
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.94 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123967 | — | — | 1 | 8.10 |
| CHEMBL338007 | — | — | 1 | 7.75 |
| CHEMBL333586 | — | — | 1 | 7.66 |
| CHEMBL332134 | — | — | 1 | 7.62 |
| CHEMBL123627 | — | — | 1 | 7.60 |
| CHEMBL124100 | — | — | 1 | 7.52 |
| CHEMBL126044 | — | — | 1 | 7.51 |
| CHEMBL125598 | — | — | 1 | 7.37 |
| CHEMBL125601 | — | — | 1 | 7.31 |
| CHEMBL123563 | — | — | 1 | 7.27 |
| CHEMBL124558 | — | — | 1 | 7.22 |
| CHEMBL436580 | — | — | 1 | 7.21 |
| CHEMBL126388 | — | — | 1 | 7.17 |
| CHEMBL331095 | — | — | 1 | 7.17 |
| CHEMBL125755 | — | — | 1 | 7.16 |
| CHEMBL123499 | — | — | 1 | 7.15 |
| CHEMBL332302 | — | — | 1 | 7.14 |
| CHEMBL419430 | — | — | 1 | 7.10 |
| CHEMBL421644 | — | — | 1 | 7.09 |
| CHEMBL339903 | — | — | 1 | 7.09 |
| CHEMBL124514 | — | — | 1 | 7.06 |
| CHEMBL338077 | — | — | 1 | 7.04 |
| CHEMBL127093 | — | — | 1 | 7.00 |
| CHEMBL123615 | — | — | 1 | 6.94 |
| CHEMBL125068 | — | — | 1 | 6.94 |
| CHEMBL339219 | — | — | 1 | 6.80 |
| CHEMBL124680 | — | — | 1 | 6.76 |
| CHEMBL340923 | — | — | 1 | 6.66 |
| CHEMBL125384 | — | — | 1 | 6.64 |
| CHEMBL123320 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123967 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL338007 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL333586 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL332134 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL123627 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL124100 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL126044 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL125598 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL125601 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL123563 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL124558 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL436580 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL126388 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL331095 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL125755 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL123499 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL332302 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL419430 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL421644 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL339903 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL124514 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL338077 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL127093 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL123615 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL125068 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL339219 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL124680 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL340923 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL125384 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL123320 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL126004 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL435206 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL124026 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL338223 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL125672 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL124265 | — | IC50 | = | 996.0 | nM | 6.00 |
| CHEMBL125281 | — | IC50 | = | 994.0 | nM | 6.00 |
| CHEMBL338453 | — | IC50 | = | 1059.0 | nM | 5.97 |
| CHEMBL124681 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL419607 | — | IC50 | = | 1320.0 | nM | 5.88 |