Assay Detail
Binding
CHEMBL715369
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Inhibition of matrix metalloprotease-1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Improved gelatinase a selectivity by novel zinc binding groups containing galardin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.25 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.52 |
| CHEMBL50209 | — | — | 1 | 8.22 |
| CHEMBL51996 | — | — | 1 | 7.30 |
| CHEMBL300902 | — | — | 1 | 7.22 |
| CHEMBL52116 | — | — | 1 | 6.14 |
| CHEMBL295950 | — | — | 1 | 6.07 |
| CHEMBL52107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL50209 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL51996 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL300902 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL52116 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL295950 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL52107 | — | IC50 | > | 10.0 | nM | - |