Assay Detail
Binding
CHEMBL715374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.12 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432882 | — | — | 1 | 7.30 |
| CHEMBL433262 | — | — | 1 | 6.96 |
| CHEMBL43479 | — | — | 1 | 6.77 |
| CHEMBL44383 | — | — | 1 | 5.82 |
| CHEMBL43113 | — | — | 1 | 5.66 |
| CHEMBL46830 | — | — | 1 | 5.50 |
| CHEMBL46818 | — | — | 1 | 5.44 |
| CHEMBL418442 | — | — | 1 | 5.38 |
| CHEMBL47254 | — | — | 1 | 5.38 |
| CHEMBL43147 | — | — | 1 | 5.27 |
| CHEMBL43152 | — | — | 1 | 5.22 |
| CHEMBL42420 | — | — | 1 | 5.21 |
| CHEMBL296196 | — | — | 1 | 5.19 |
| CHEMBL44062 | — | — | 1 | 5.16 |
| CHEMBL539683 | — | — | 1 | 5.07 |
| CHEMBL44455 | — | — | 1 | 4.92 |
| CHEMBL432307 | — | — | 1 | 4.89 |
| CHEMBL42938 | — | — | 1 | 4.85 |
| CHEMBL43063 | — | — | 1 | 4.82 |
| CHEMBL45040 | — | — | 1 | 4.75 |
| CHEMBL43644 | — | — | 1 | 4.62 |
| CHEMBL42114 | — | — | 1 | 4.58 |
| CHEMBL47076 | — | — | 1 | 4.57 |
| CHEMBL42067 | — | — | 1 | 4.54 |
| CHEMBL291133 | — | — | 1 | 4.40 |
| CHEMBL297749 | — | — | 1 | 4.39 |
| CHEMBL44898 | — | — | 1 | 4.30 |
| CHEMBL295871 | — | — | 1 | 4.25 |
| CHEMBL43276 | — | — | 1 | 4.25 |
| CHEMBL43206 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432882 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL433262 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL43479 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL44383 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL43113 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL46830 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL46818 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL418442 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL47254 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL43147 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL43152 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL42420 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL296196 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL44062 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL539683 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL44455 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL432307 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL42938 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL43063 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL45040 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL43644 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL42114 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL47076 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL42067 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL291133 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL297749 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL44898 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL295871 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL43276 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL43206 | — | IC50 | = | 100000.0 | nM | 4.00 |