Assay Detail
Binding
CHEMBL715378
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Inhibition of matrix metalloprotease-1, Collagenase-1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.82 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16520 | RO-319790 | — | 1 | 8.30 |
| CHEMBL16519 | — | — | 1 | 8.30 |
| CHEMBL16554 | — | — | 1 | 8.00 |
| CHEMBL16630 | — | — | 1 | 7.96 |
| CHEMBL16933 | — | — | 1 | 7.96 |
| CHEMBL16505 | — | — | 1 | 7.34 |
| CHEMBL16650 | — | — | 1 | 6.85 |
| CHEMBL16595 | — | — | 1 | - |
| CHEMBL17082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16520 | RO-319790 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL16519 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL16554 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL16630 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL16933 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL16505 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL16650 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL16595 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL17082 | — | IC50 | > | 4000.0 | nM | - |