Assay Detail
Binding
CHEMBL715380
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Inhibitory activity against MMP-1 (Matrix metalloprotease-1)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.33 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144611 | — | — | 1 | 9.06 |
| CHEMBL144843 | — | — | 1 | 8.96 |
| CHEMBL344759 | — | — | 1 | 8.92 |
| CHEMBL342100 | — | — | 1 | 8.89 |
| CHEMBL344060 | — | — | 1 | 8.82 |
| CHEMBL439983 | — | — | 1 | 8.77 |
| CHEMBL144525 | — | — | 1 | 8.66 |
| CHEMBL144568 | — | — | 1 | 8.66 |
| CHEMBL342732 | — | — | 1 | 8.62 |
| CHEMBL144293 | — | — | 1 | 8.59 |
| CHEMBL147051 | — | — | 1 | 8.55 |
| CHEMBL29976 | — | — | 1 | 8.40 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.30 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.09 |
| CHEMBL16520 | RO-319790 | — | 1 | 8.00 |
| CHEMBL432079 | — | — | 1 | 8.00 |
| CHEMBL358962 | — | — | 1 | 6.48 |
| CHEMBL148331 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144611 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL144843 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL344759 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL342100 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL344060 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL439983 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL144525 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL144568 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL342732 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL144293 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL147051 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL29976 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL16520 | RO-319790 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL432079 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL358962 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL148331 | — | IC50 | = | 730.0 | nM | 6.14 |