Assay Detail
Binding
CHEMBL715382
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Inhibitory activity against human Matrix metalloprotease-1
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.39 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.54 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.46 |
| CHEMBL93231 | — | — | 1 | 6.89 |
| CHEMBL92899 | — | — | 3 | 6.52 |
| CHEMBL94248 | — | — | 1 | 6.16 |
| CHEMBL91124 | — | — | 1 | 5.92 |
| CHEMBL90211 | — | — | 1 | 5.80 |
| CHEMBL92923 | — | — | 1 | 5.63 |
| CHEMBL433171 | — | — | 1 | 5.62 |
| CHEMBL90762 | — | — | 1 | 5.36 |
| CHEMBL90487 | — | — | 1 | - |
| CHEMBL329659 | — | — | 1 | - |
| CHEMBL419315 | — | — | 1 | - |
| CHEMBL92778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL93231 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL92899 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL92899 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL94248 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL91124 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL90211 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL92923 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL433171 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL90762 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL90487 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL329659 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL419315 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL92899 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL92778 | — | IC50 | > | 10000.0 | nM | - |